Ryr3^tm2Tno
Targeted Allele Detail

Summary

• Symbol: Ryr3^tm2Tno
• Name: ryanodine receptor 3; targeted mutation 2, Tetsuo Noda
• MGI ID: MGI:2429753
• Gene: Ryr3 Location: Chr2:112461700-113047441 bp, - strand Genetic Position: Chr2, 57.2 cM, cytoband E5-F3
• Alliance: Ryr3^tm2Tno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:34908
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: Exon 2 was replaced with a neomycin selection cassette inserted by homologous recombination. No protein was detected by Western blot analysis of brain tissue obtained from homozygous mutant mice. (J:34908)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ryr3 Mutation: 261 strains or lines available

References

• Original: J:34908 Takeshima H, et al., Generation and characterization of mutant mice lacking ryanodine receptor type 3. J Biol Chem. 1996 Aug 16;271(33):19649-52
• All: 2 reference(s)