Dvl2^tm1Awb
Targeted Allele Detail

Summary

• Symbol: Dvl2^tm1Awb
• Name: dishevelled segment polarity protein 2; targeted mutation 1, Anthony Wynshaw-Boris
• MGI ID: MGI:2429760
• Synonyms: Dvl2^-
• Gene: Dvl2 Location: Chr11:69891418-69900935 bp, + strand Genetic Position: Chr11, 42.96 cM
• Alliance: Dvl2^tm1Awb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79834
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette inserted by homologous recombination replaced a portion of exon 2 and all of exons 3 through 6. Western blot analysis of homozygous mutant brain lysates indicated an absence of protein. (J:79834)

Disease models

Expression

In Mice Carrying this Mutation:	16 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dvl2 Mutation: 35 strains or lines available

References

• Original: J:79834 Hamblet NS, et al., Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure. Development. 2002 Dec;129(24):5827-38
• All: 13 reference(s)