Pparg^tm1Tka
Targeted Allele Detail

Summary

• Symbol: Pparg^tm1Tka
• Name: peroxisome proliferator activated receptor gamma; targeted mutation 1, Takashi Kadowaki
• MGI ID: MGI:2429766
• Synonyms: PPARgamma^-
• Gene: Pparg Location: Chr6:115337912-115467360 bp, + strand Genetic Position: Chr6, 53.41 cM, cytoband E3-F1
• Alliance: Pparg^tm1Tka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58222
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted in exon 1 immediately upstream of the endogenous start codon. Northern blot analysis of homozygous mutant mice indicated an absence of transcript. (J:58222)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pparg Mutation: 41 strains or lines available

References

• Original: J:58222 Kubota N, et al., PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol Cell. 1999 Oct;4(4):597-609
• All: 12 reference(s)