Snca^tm1Wtd
Targeted Allele Detail

Summary

• Symbol: Snca^tm1Wtd
• Name: synuclein, alpha; targeted mutation 1, William T Dauer
• MGI ID: MGI:2429773
• Gene: Snca Location: Chr6:60708559-60806839 bp, - strand Genetic Position: Chr6, 29.15 cM
• Alliance: Snca^tm1Wtd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79993
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence, Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: A floxed region containing neo and a transcriptional blocking sequence (STOP) was followed by human sequence encoding a modified SNCA gene. This construct was incorporated 7 bp upstream of the endogenous start codon via homologous recombination. Northern and Western blot analyses of homozygous mutant mice indicated a complete ablation of gene expression. The positioning of the human sequence downstream of the transcription blocking cassette precluded its expression. (J:79993)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Snca Mutation: 36 strains or lines available

References

• Original: J:79993 Dauer W, et al., Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14524-9
• All: 5 reference(s)