Glb1^tm1Jmat
Targeted Allele Detail

Summary

• Symbol: Glb1^tm1Jmat
• Name: galactosidase, beta 1; targeted mutation 1, Junichiro Matsuda
• MGI ID: MGI:2429923
• Synonyms: betaGal^-
• Gene: Glb1 Location: Chr9:114230146-114303447 bp, + strand Genetic Position: Chr9, 64.4 cM
• Alliance: Glb1^tm1Jmat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43534
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Exon 15 was disrupted by the insertion of a neomycin selection cassette. Only residual beta-galactosidase activity was detected in brain tissue obtained from homozygous mutant mice. Higher levels of residual activity were observed in spleen, testes, and renal tissues. (J:43534)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Glb1 Mutation: 50 strains or lines available

References

• Original: J:43534 Matsuda J, et al., Beta-galactosidase-deficient mouse as an animal model for GM1-gangliosidosis. Glycoconj J. 1997 Sep;14(6):729-36
• All: 8 reference(s)