Pml^tm1Ppp
Targeted Allele Detail

Summary

• Symbol: Pml^tm1Ppp
• Name: promyelocytic leukemia; targeted mutation 1, Pier P Pandolfi
• MGI ID: MGI:2429949
• Synonyms: PML^-
• Gene: Pml Location: Chr9:58125359-58157069 bp, - strand Genetic Position: Chr9, 31.63 cM
• Alliance: Pml^tm1Ppp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46381
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 2, which encodes the RING-finger domain, was replaced with a neomycin resistance cassette. (J:46381)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Pml^tm1Ppp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Pml Mutation: 92 strains or lines available

References

• Original: J:46381 Wang ZG, et al., Role of PML in cell growth and the retinoic acid pathway. Science. 1998 Mar 6;279(5356):1547-51
• All: 46 reference(s)