Aprt^tm1Dwm
Targeted Allele Detail

Summary

• Symbol: Aprt^tm1Dwm
• Name: adenine phosphoribosyl transferase; targeted mutation 1, David W Melton
• MGI ID: MGI:2429961
• Gene: Aprt Location: Chr8:123301376-123303646 bp, - strand Genetic Position: Chr8, 71.91 cM
• Alliance: Aprt^tm1Dwm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:38450
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encompassing exons 1 and 2 was replaced with a neomycin selection cassette. The incorporation of labeled adenine in homozygous mutant mice was 0.5% of the wild-type level. (J:38450)

Disease models

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aprt Mutation: 18 strains or lines available

References

• Original: J:38450 Redhead NJ, et al., Mice with adenine phosphoribosyltransferase deficiency develop fatal 2,8-dihydroxyadenine lithiasis. Hum Gene Ther. 1996 Aug 20;7(13):1491-502
• All: 1 reference(s)