Ccnb1^tm1Thnt
Targeted Allele Detail

Summary

• Symbol: Ccnb1^tm1Thnt
• Name: cyclin B1; targeted mutation 1, Tim Hunt
• MGI ID: MGI:2429976
• Gene: Ccnb1 Location: Chr13:100915247-100922994 bp, - strand Genetic Position: Chr13, 53.23 cM
• Alliance: Ccnb1^tm1Thnt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47430
• Parent Cell Line: GK129 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence extending from within exon 5 into exon 9 was replaced by a Beta-geo cassette inserted by homologous recombination. The deleted region included the cyclin box which is involved in the binding of cell cycle division 2. (J:47430)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccnb1 Mutation: 37 strains or lines available

References

• Original: J:47430 Brandeis M, et al., Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4344-9
• All: 4 reference(s)