Nup214^tm1Gcg
Targeted Allele Detail

Summary

• Symbol: Nup214^tm1Gcg
• Name: nucleoporin 214; targeted mutation 1, Gerard C Grosveld
• MGI ID: MGI:2441651
• Synonyms: CAN-
• Gene: Nup214 Location: Chr2:31864446-31943204 bp, + strand Genetic Position: Chr2, 21.97 cM
• Alliance: Nup214^tm1Gcg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:36515
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The endogenous locus was disrupted by the insertion of an IRES-lacZneo cassette into a PvuII restriction site. The site of insertion corresponds with human codon 297. (J:36515)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nup214 Mutation: 84 strains or lines available

References

• Original: J:36515 van Deursen J, et al., G2 arrest and impaired nucleocytoplasmic transport in mouse embryos lacking the proto-oncogene CAN/Nup214. EMBO J. 1996 Oct 15;15(20):5574-83
• All: 1 reference(s)