Nr3c2^tm1Gsc
Targeted Allele Detail

Summary

• Symbol: Nr3c2^tm1Gsc
• Name: nuclear receptor subfamily 3, group C, member 2; targeted mutation 1, Gunther Schutz
• MGI ID: MGI:2441654
• Synonyms: MR-
• Gene: Nr3c2 Location: Chr8:77626422-77971641 bp, + strand Genetic Position: Chr8, 36.34 cM
• Alliance: Nr3c2^tm1Gsc page

Histological and immunocytochemical kidney analysis of Nr3c2^tm1Gsc/Nr3c2^tm1Gsc mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77285
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The majority of exon 3, which encodes the first zinc finger of the DNA binding domain, was replaced with a cassette containing lacZ and neo. RT-PCR showed the presence of a fusion transcript containing lacZ in place of endogenous exon 3 sequence. (J:77285)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr3c2 Mutation: 53 strains or lines available

References

• Original: J:77285 Berger S, et al., Mineralocorticoid receptor knockout mice: pathophysiology of Na+ metabolism. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9424-9
• All: 10 reference(s)