Glis1^tm1Mnks
Targeted Allele Detail

Summary

• Symbol: Glis1^tm1Mnks
• Name: GLIS family zinc finger 1; targeted mutation 1, Misako Nakashima
• MGI ID: MGI:2445222
• Synonyms: GliH1^lz
• Gene: Glis1 Location: Chr4:107291788-107492258 bp, + strand Genetic Position: Chr4, 50.18 cM, cytoband C6
• Alliance: Glis1^tm1Mnks page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80052
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 840 bp of exon 2, encompassing the start codon and sequence encoding the first 2 zinc finger domains, were replaced with a lacZ-neo cassette. Normal transcript was undetected by Northern blot analysis of homozygous mutant mice. Comparison with in situ hybridization results indicated that the lacZ expression pattern was similar to that of the endogenous gene. (J:80052)

Expression

In Mice Carrying this Mutation:

8 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Glis1 Mutation: 37 strains or lines available

References

• Original: J:80052 Nakashima M, et al., A novel gene, GliH1, with homology to the Gli zinc finger domain not required for mouse development. Mech Dev. 2002 Nov;119(1):21
• All: 1 reference(s)