Mst1^tm1Jab
Targeted Allele Detail

Summary

• Symbol: Mst1^tm1Jab
• Name: macrophage stimulating 1 (hepatocyte growth factor-like); targeted mutation 1, Jorge A Bezerra
• MGI ID: MGI:2445230
• Synonyms: HGFL^-
• Gene: Mst1 Location: Chr9:107957635-107962202 bp, + strand Genetic Position: Chr9, 59.07 cM
• Alliance: Mst1^tm1Jab page

Livers of Mst1^tm1Jab/Mst1^tm1Jab mice display cytoplasmic vacuolization of hepatocytes

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46185
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encompassing a portion of exon 3 and all of exons 4 through 7 was replaced by a PGK-hprt cassette. Endogenous mRNA was undetected by Northern blot analysis of liver tissue obtained from homozygous mutant mice. Western blot analysis of sera indicated an absence of protein. (J:46185)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mst1 Mutation: 40 strains or lines available

References

• Original: J:46185 Bezerra JA, et al., Biological effects of targeted inactivation of hepatocyte growth factor-like protein in mice. J Clin Invest. 1998 Mar 1;101(5):1175-83
• All: 5 reference(s)