Tbxa2rtm1Cof
Targeted Allele Detail
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Symbol: |
Tbxa2rtm1Cof |
Name: |
thromboxane A2 receptor; targeted mutation 1, Thomas M Coffman |
MGI ID: |
MGI:2445297 |
Synonyms: |
Tp-, TPKO, tpr- |
Gene: |
Tbxa2r Location: Chr10:81164565-81171006 bp, + strand Genetic Position: Chr10, 39.72 cM
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Alliance: |
Tbxa2rtm1Cof page
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Germline Transmission: |
Earliest citation of germline transmission:
J:52125
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Parent Cell Line: |
E14TG2a (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Insertion
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Mutation details: The insertion of a PGK-neo cassette into exon 2 disrupted sequence encoding the third transmembrane domain. Though Northern blot analysis identified several aberrant transcripts in homozygous mutant mice, no normal transcript was detected. Binding assays using a labeled thromboxane agonist indicated an absence of functional receptors in both thymocytes and renal sections obtained from homozygous mutant mice.
(J:52125)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Tbxa2r Mutation: |
18 strains or lines available
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Original: |
J:52125 Thomas DW, et al., Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2. J Clin Invest. 1998 Dec 1;102(11):1994-2001 |
All: |
20 reference(s) |
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