Nxph1^tm1Sud
Targeted Allele Detail

Summary

• Symbol: Nxph1^tm1Sud
• Name: neurexophilin 1; targeted mutation 1, Thomas C Sudhof
• MGI ID: MGI:2445315
• Synonyms: Nph1-
• Gene: Nxph1 Location: Chr6:8948431-9249032 bp, + strand Genetic Position: Chr6, 4.38 cM, cytoband A1
• Alliance: Nxph1^tm1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51648
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted exon encoded the majority of the protein, lacking only sequence encoding the signal peptide. mRNA was undetected in homozygous mutant mice by Northern blot analysis. (J:51648)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nxph1 Mutation: 15 strains or lines available

References

• Original: J:51648 Missler M, et al., Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit. J Biol Chem. 1998 Dec 25;273(52):34716-23
• All: 3 reference(s)