St3gal2^tm1Jxm
Targeted Allele Detail

Summary

• Symbol: St3gal2^tm1Jxm
• Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 2; targeted mutation 1, Jamey Marth
• MGI ID: MGI:2445397
• Synonyms: ST3Gal-II^delta
• Gene: St3gal2 Location: Chr8:111646554-111699112 bp, + strand Genetic Position: Chr8, 57.81 cM
• Alliance: St3gal2^tm1Jxm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80119
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A single loxP site was left in place of the exon encoding the sialyl motif essential for donor substrate binding and catalytic activity after it was flanked by loxP sites and subsequently excised via in vitro cre mediated recombination. (J:80119)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any St3gal2 Mutation: 37 strains or lines available

References

• Original: J:80119 Ellies LG, et al., Sialyltransferase specificity in selectin ligand formation. Blood. 2002 Nov 15;100(10):3618-25
• All: 8 reference(s)