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Rr349tm1.1Wgw
Targeted Allele Detail
Summary
Symbol: Rr349tm1.1Wgw
Name: regulatory region 349; targeted mutation 1.1, William G Wood
MGI ID: MGI:2445400
Synonyms: delta R2, Hba/Maretm1.1Wgw, Maretm1.1Wgw, mHS -26-, mHS -26KO, Nprl3tm1.1Wgw
Gene: Rr349  Location: unknown  Genetic Position: Chr11, Syntenic
Alliance: Rr349tm1.1Wgw page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:80121
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Modified regulatory region)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 1312 bp sequence containing the Hba erythroid regulatory element (HS -26), located in Nprl3 intron 4 and containing transcription factor binding elements for the hemoglobin alpha genes, was replaced with a loxP site flanked neomycin resistance gene cassette. The neo cassette was removed through subsequent cre-mediated recombination, after which Nprl3 expression was restored to normal. The open reading frame of Nprl3 remained undisrupted. (J:80121)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rr349 Mutation:  0 strains or lines available
References
Original:  J:80121 Anguita E, et al., Deletion of the mouse alpha-globin regulatory element (HS -26) has an unexpectedly mild phenotype. Blood. 2002 Nov 15;100(10):3450-6
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory