Rr349tm1.1Wgw
Targeted Allele Detail
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Symbol: |
Rr349tm1.1Wgw |
Name: |
regulatory region 349; targeted mutation 1.1, William G Wood |
MGI ID: |
MGI:2445400 |
Synonyms: |
delta R2, Hba/Maretm1.1Wgw, Maretm1.1Wgw, mHS -26-, mHS -26KO, Nprl3tm1.1Wgw |
Gene: |
Rr349 Location: unknown Genetic Position: Chr11, Syntenic
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Alliance: |
Rr349tm1.1Wgw page
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Germline Transmission: |
Earliest citation of germline transmission:
J:80121
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Parent Cell Line: |
E14TG2a (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Modified regulatory region) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A 1312 bp sequence containing the Hba erythroid regulatory element (HS -26), located in Nprl3 intron 4 and containing transcription factor binding elements for the hemoglobin alpha genes, was replaced with a loxP site flanked neomycin resistance gene cassette. The neo cassette was removed through subsequent cre-mediated recombination, after which Nprl3 expression was restored to normal. The open reading frame of Nprl3 remained undisrupted.
(J:80121)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Rr349 Mutation: |
0 strains or lines available
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Original: |
J:80121 Anguita E, et al., Deletion of the mouse alpha-globin regulatory element (HS -26) has an unexpectedly mild phenotype. Blood. 2002 Nov 15;100(10):3450-6 |
All: |
3 reference(s) |
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