Mapk7^tm1Wnt
Targeted Allele Detail

Summary

• Symbol: Mapk7^tm1Wnt
• Name: mitogen-activated protein kinase 7; targeted mutation 1, Astar Winoto
• MGI ID: MGI:2445409
• Synonyms: ERK5^-
• Gene: Mapk7 Location: Chr11:61379638-61385101 bp, - strand Genetic Position: Chr11, 37.96 cM
• Alliance: Mapk7^tm1Wnt page

Mapk7^tm1Wnt/Mapk7^tm1Wntembryos exhibit retarded growth and vascular defects in the yolk sacs

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80044
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 3.7 kb of genomic sequence were replaced with a floxed neomycin selection cassette inserted by homologous recombination. The deleted region included 1.8 kb of coding sequence encoding the initiator methionine and the kinase domain. No protein was detected by Western blot analysis of homozygous embryonic lysates. (J:80044)

Expression

In Mice Carrying this Mutation:	68 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapk7 Mutation: 32 strains or lines available

References

• Original: J:80044 Sohn SJ, et al., ERK5 MAPK regulates embryonic angiogenesis and acts as a hypoxia-sensitive repressor of vascular endothelial growth factor expression. J Biol Chem. 2002 Nov 8;277(45):43344-51
• All: 2 reference(s)