Rr320^tm2.1Mkg
Targeted Allele Detail

Summary

• Symbol: Rr320^tm2.1Mkg
• Name: regulatory region 320; targeted mutation 2.1, Mark Groudine
• MGI ID: MGI:2445412
• Synonyms: deltaHS2deltaneo, Hbb-ar^tm2.1Mkg
• Gene: Rr320 Location: Chr7:103501973-103526752 bp, + strand Genetic Position: Chr7, Syntenic
• Alliance: Rr320^tm2.1Mkg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28981
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele is derived from Rr320^tm2Mkg. In embryonic stem cells derived from Rr320^tm2Mkg animals, the FRT site flanked neomycin resistance gene cassette which replaces HS2 was removed by transient expression of flp recombinase. (J:28981)

Expression

In Mice Carrying this Mutation:

36 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr320 Mutation: 0 strains or lines available

References

• Original: J:28981 Fiering S, et al., Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus. Genes Dev. 1995 Sep 15;9(18):2203-13
• All: 3 reference(s)