Sgk1^tm1Kuhl
Targeted Allele Detail

Summary

• Symbol: Sgk1^tm1Kuhl
• Name: serum/glucocorticoid regulated kinase 1; targeted mutation 1, Dietmar Kuhl
• MGI ID: MGI:2445418
• Synonyms: sgk1^-
• Gene: Sgk1 Location: Chr10:21758083-21875802 bp, + strand Genetic Position: Chr10, 9.83 cM, cytoband A3
• Alliance: Sgk1^tm1Kuhl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80115
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A region containing exons 4 through 11 was deleted by in vitro cre mediated recombination of a single loxP site inserted in intron 3 and a floxed neo cassette downstream of exon 11. The deleted region encoded the entire kinase domain. A shortened transcript, corresponding to a 0.9 kb deletion, was identified in homozygous mutant mice by Northern blot analysis. (J:80115)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sgk1 Mutation: 151 strains or lines available

References

• Original: J:80115 Wulff P, et al., Impaired renal Na(+) retention in the sgk1-knockout mouse. J Clin Invest. 2002 Nov;110(9):1263-8
• All: 34 reference(s)