Jun^tm4Wag
Targeted Allele Detail

Summary

• Symbol: Jun^tm4Wag
• Name: jun proto-oncogene; targeted mutation 4, Erwin F Wagner
• MGI ID: MGI:2445420
• Synonyms: c-jun^f, jun^f, Jun^flox
• Gene: Jun Location: Chr4:94937273-94940459 bp, - strand Genetic Position: Chr4, 43.34 cM, cytoband C5-C7
• Alliance: Jun^tm4Wag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75863
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The gene was flanked with a loxP site and a floxed neo-TK cassette via homologous recombination. The neo-TK cassette was removed in correctly targeted ES cells by transient expression of cre recombinase. The resulting mutation consists of Jun flanked by single loxP sites. (J:75863)

Disease models

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	15 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Jun^tm4Wag

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jun Mutation: 12 strains or lines available

References

• Original: J:75863 Behrens A, et al., Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver. EMBO J. 2002 Apr 2;21(7):1782-90
• All: 72 reference(s)