Cdc25a^m1Rfp
Spontaneous Allele Detail

Summary

• Symbol: Cdc25a^m1Rfp
• Name: cell division cycle 25A; mutation 1, Robert F Paulson
• MGI ID: MGI:2445422
• Synonyms: Cdc25A^His128Gln
• Gene: Cdc25a Location: Chr9:109704647-109722963 bp, + strand Genetic Position: Chr9, 59.81 cM
• Alliance: Cdc25a^m1Rfp page

Mutation origin

• Strain of Origin: BALB/cJ

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: A transversion mutation (C to A) resulted in a histidine to glutamine substitution at codon 128. The mutation is in a region of 24 conserved residues in the amino terminal non-catalytic domain and was demonstrated by biochemical assays to confer increased phosphatase activity. Identification of this allele was facilitated by linkage to Mst1r^Fv2. (J:80142)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdc25a Mutation: 34 strains or lines available

References

• Original: J:80142 Melkun E, et al., A naturally occurring point substitution in Cdc25A, and not Fv2/Stk, is associated with altered cell-cycle status of early erythroid progenitor cells. Blood. 2002 Nov 15;100(10):3804-11
• All: 1 reference(s)