Pitx2^tm3Jfm
Targeted Allele Detail

Summary

• Symbol: Pitx2^tm3Jfm
• Name: paired-like homeodomain transcription factor 2; targeted mutation 3, James F Martin
• MGI ID: MGI:2445425
• Synonyms: deltac neo
• Gene: Pitx2 Location: Chr3:128993527-129013240 bp, + strand Genetic Position: Chr3, 57.84 cM
• Alliance: Pitx2^tm3Jfm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79853
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4 was replaced with a floxed neomycin selection cassette. Mice harboring this allele were crossed with transgenic mice expressing cre recombinase to generate an Pitx2^tm3.1Jfm, which encodes isoforms a and b, but not the heart- and lung-specific c isoform. (J:79853)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pitx2 Mutation: 39 strains or lines available

References

• Original: J:79853 Liu C, et al., Pitx2c patterns anterior myocardium and aortic arch vessels and is required for local cell movement into atrioventricular cushions. Development. 2002 Nov;129(21):5081-91
• All: 4 reference(s)