Tg(COL2A1-cre)1Wag
Transgene Detail

Summary

• Symbol: Tg(COL2A1-cre)1Wag
• Name: transgene insertion 1, Erwin F Wagner
• MGI ID: MGI:2445431
• Synonyms: Col2-Cre, collagen2a1-cre
• Transgene: Tg(COL2A1-cre)1Wag Location: unknown
• Alliance: Tg(COL2A1-cre)1Wag page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(COL2A1-cre)1Wag expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  COL2A1 (1280)

  Col2a1

  (MGI:88452)

• Mutation details: This transgene expresses cre recombinase under the control of human COL2A1 promoter and enhancer sequences. Human COL2A1 promoter and enhancer sequences drive transgene expression. Transgene expression is observed in chondrogenic tissues, the developing eye, epidermis, heart myocardium, and endoderm of the developing yolk sac. (J:60838)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	COL2A1 (human) Summary of all recombinase alleles driven by COL2A1. Comparative matrix view of recombinase activities Alliance human COL2A1 gene page

Expression

In Mice Carrying this Mutation:

13 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:60838 Haigh JJ, et al., Conditional inactivation of VEGF-A in areas of collagen2a1 expression results in embryonic lethality in the heterozygous state. Development. 2000 Apr;127(7):1445-53
• All: 4 reference(s)