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Procrtm1Cte
Targeted Allele Detail
Summary
Symbol: Procrtm1Cte
Name: protein C receptor, endothelial; targeted mutation 1, Charles T Esmon
MGI ID: MGI:2445432
Synonyms: EPCR-
Gene: Procr  Location: Chr2:155593037-155597391 bp, + strand  Genetic Position: Chr2, 77.26 cM, cytoband H1-3
Alliance: Procrtm1Cte page
Procrtm1Cte/Procrtm1Cte embryos are small at E8, growth retarded by E9.5, and do not complete axial rotation

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:80043
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExon 1 was flanked by loxP sites and subsequently excised via in vitro cre mediated recombination. The resultant germline allele contained a single loxP site in place of exon 1, which included the 5' untranslated region and encoded the start codon, signal peptide, and part of the extracellular domain. RT-PCR indicated an absence of transcript in homozygous mutant embryos. (J:80043)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 4 assay results
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Procr Mutation:  17 strains or lines available
Notes
ES cell line = AB2.
References
Original:  J:80043 Gu JM, et al., Disruption of the endothelial cell protein C receptor gene in mice causes placental thrombosis and early embryonic lethality. J Biol Chem. 2002 Nov 8;277(45):43335-43
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory