Rb1^tm1.1Jyjw
Targeted Allele Detail

Summary

• Symbol: Rb1^tm1.1Jyjw
• Name: RB transcriptional corepressor 1; targeted mutation 1.1, Jean YJ Wang
• MGI ID: MGI:2445439
• Synonyms: MI-deltaNeo, Rb^MI
• Gene: Rb1 Location: Chr14:73430298-73563446 bp, - strand Genetic Position: Chr14, 38.73 cM, cytoband D3
• Alliance: Rb1^tm1.1Jyjw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80087
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: This mutant is derived from Rb1^tm1Jyjw. The floxed neo cassette in intron 25 was removed by mating Rb1^tm1Jyjw animals to cre-expressing line TgN(Prm-cre)58Og. Resulting progeny contain the aspartic acid to alanine mutation in the caspase cleavage site of exon 25 and the diagnostic EcoRI site in intron 24. (J:80087)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rb1 Mutation: 111 strains or lines available

References

• Original: J:80087 Chau BN, et al., Signal-dependent protection from apoptosis in mice expressing caspase-resistant Rb. Nat Cell Biol. 2002 Oct;4(10):757-65
• All: 3 reference(s)