Pex11a^tm1Sjg
Targeted Allele Detail

Summary

• Symbol: Pex11a^tm1Sjg
• Name: peroxisomal biogenesis factor 11 alpha; targeted mutation 1, Stephen J Gould
• MGI ID: MGI:2445440
• Synonyms: PEX11alpha^-
• Gene: Pex11a Location: Chr7:79385705-79392879 bp, - strand Genetic Position: Chr7, 45.12 cM, cytoband D2
• Alliance: Pex11a^tm1Sjg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80124
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 encoding amino acids 227-246 were deleted and replaced with a PGK-neo cassette via homologous recombination. Northern blot analysis of total liver mRNA from homozygous mutant animals did not detect gene product. (J:80124)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pex11a Mutation: 8 strains or lines available

References

• Original: J:80124 Li X, et al., PEX11alpha is required for peroxisome proliferation in response to 4-phenylbutyrate but is dispensable for peroxisome proliferator-activated receptor alpha-mediated peroxisome proliferation. Mol Cell Biol. 2002 Dec;22(23):8226-40
• All: 1 reference(s)