Socs1^tm1Kish
Targeted Allele Detail

Summary

• Symbol: Socs1^tm1Kish
• Name: suppressor of cytokine signaling 1; targeted mutation 1, Tadamitsu Kishimoto
• MGI ID: MGI:2445448
• Synonyms: SSI-1-
• Gene: Socs1 Location: Chr16:10601672-10603400 bp, - strand Genetic Position: Chr16, 5.81 cM
• Alliance: Socs1^tm1Kish page

Histological appearances of the spleen and thymus in Socs1^tm1Kish/Socs1^tm1Kish mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51685
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A large portion of exon 2 (approximately 0.6 kb of genomic sequence) was replaced with a PGK-neo cassette via homologous recombination. Northern blot analysis of lung tissue RNA confirmed the absence of gene expression in homozygous mutant animals. (J:51685)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Socs1 Mutation: 30 strains or lines available

References

• Original: J:51685 Naka T, et al., Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15577-82
• All: 11 reference(s)