Xist^tm2.1Jae
Targeted Allele Detail

Summary

• Symbol: Xist^tm2.1Jae
• Name: inactive X specific transcripts; targeted mutation 2.1, Rudolf Jaenisch
• MGI ID: MGI:2445460
• Synonyms: deltaXist, Xist^1lox
• Gene: Xist Location: ChrX:102503979-102526839 bp, - strand Genetic Position: ChrX, 46.15 cM, cytoband D
• Alliance: Xist^tm2.1Jae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80117
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 1, 2, and 3 as well as 5 kb of the proximal promoter were deleted via cre mediated recombination of single loxP sites in the 5' untranslated region and intron 3. Though complete transcriptional ablation was previously reported by Csankocszki et al., 1999 (J:75502), Turner et al., 2002 (J:80117) reported an endogenous testis-specific transcript that utilizes an upstream promoter in wild-type mice and therefore is putatively present in mutant mice. The deleted region encoded a domain essential for X chromosome inactivation. (J:75502, J:80117)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Xist Mutation: 8 strains or lines available

References

• Original: J:80117 Turner JM, et al., Meiotic sex chromosome inactivation in male mice with targeted disruptions of Xist. J Cell Sci. 2002 Nov 1;115(Pt 21):4097-105
• All: 7 reference(s)