Pax8^tm1(cre)Mbu
Targeted Allele Detail

Summary

• Symbol: Pax8^tm1(cre)Mbu
• Name: paired box 8; targeted mutation 1, Meinrad Busslinger
• MGI ID: MGI:2445461
• Synonyms: Pax8^-, Pax8^neo
• Gene: Pax8 Location: Chr2:24310572-24365611 bp, - strand Genetic Position: Chr2, 16.43 cM, cytoband B
• Alliance: Pax8^tm1(cre)Mbu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80208
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Pax8^tm1(cre)Mbu expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pax8 (MGI:97492)

• Mutation details: The gene was disrupted by replacement of exon 3 with an in-frame cre recombinase and frt-flanked neo cassette via homologous recombination. The targeted mutation deletes the N-terminal portion of the paired domain, which is essential for DNA-binding. (J:80208)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pax8 (mouse) Summary of all recombinase alleles driven by Pax8. Alliance mouse Pax8 gene page

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pax8 Mutation: 32 strains or lines available

References

• Original: J:80208 Bouchard M, et al., Nephric lineage specification by Pax2 and Pax8. Genes Dev. 2002 Nov 15;16(22):2958-70
• All: 14 reference(s)