Pes1^tm1Sad
Targeted Allele Detail

Summary

• Symbol: Pes1^tm1Sad
• Name: pescadillo ribosomal biogenesis factor 1; targeted mutation 1, Stephen A Duncan
• MGI ID: MGI:2445464
• Synonyms: pes^-
• Gene: Pes1 Location: Chr11:3913975-3930004 bp, + strand Genetic Position: Chr11, 2.79 cM
• Alliance: Pes1^tm1Sad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80174
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence extending from the 158 3' bases of exon 5 through the first 110 bases of exon 12 was replaced by a PGK-neo cassette inserted by homologous recombination. (J:80174)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pes1 Mutation: 38 strains or lines available

References

• Original: J:80174 Lerch-Gaggl A, et al., Pescadillo is essential for nucleolar assembly, ribosome biogenesis, and Mammalian cell proliferation. J Biol Chem. 2002 Nov 22;277(47):45347-55
• All: 1 reference(s)