Gja5^tm1Paul
Targeted Allele Detail

Summary

• Symbol: Gja5^tm1Paul
• Name: gap junction protein, alpha 5; targeted mutation 1, David L Paul
• MGI ID: MGI:2445466
• Synonyms: Cx40-
• Gene: Gja5 Location: Chr3:96939718-96960950 bp, + strand Genetic Position: Chr3, 42.04 cM
• Alliance: Gja5^tm1Paul page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46430
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The single coding exon of the gene was deleted and replaced with a PGK-neo cassette via homologous recombination. Absence of gene expression was confirmed by immunohistochemical analysis of frozen heart sections from homozygous mutant animals. (J:46430)

Disease models

Expression

In Mice Carrying this Mutation:	36 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gja5 Mutation: 19 strains or lines available

References

• Original: J:46430 Simon AM, et al., Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block. Curr Biol. 1998 Feb 26;8(5):295-8
• All: 29 reference(s)