Gja1^tm1.1Kwi
Targeted Allele Detail

Summary

• Symbol: Gja1^tm1.1Kwi
• Name: gap junction protein, alpha 1; targeted mutation 1., Klaus Willecke
• MGI ID: MGI:2445472
• Synonyms: Cx43^del
• Gene: Gja1 Location: Chr10:56253297-56266519 bp, + strand Genetic Position: Chr10, 28.64 cM
• Alliance: Gja1^tm1.1Kwi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78662
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region contained within loxP sites flanking exon 2 and the floxed tk-neo cassette were removed by mating Gja1^tm1Kwi animals to cre deleter strain TgN(CMV-cre)1Cgn. Resulting progeny retained a single loxP site and lacZ cassette. (J:78662)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gja1 Mutation: 60 strains or lines available

References

• Original: J:78662 Theis M, et al., Endothelium-specific replacement of the connexin43 coding region by a lacZ reporter gene. Genesis. 2001 Jan;29(1):1-13
• All: 16 reference(s)