Tg(GFAP-SRC)2Aag
Transgene Detail

Summary

• Symbol: Tg(GFAP-SRC)2Aag
• Name: transgene insertion 2, Adriano Aguzzi
• MGI ID: MGI:2445477
• Synonyms: src2
• Transgene: Tg(GFAP-SRC)2Aag Location: unknown
• Alliance: Tg(GFAP-SRC)2Aag page

Transgene origin

• Strain of Origin: (C57BL/6J x C3H)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene was constructed by insertion of a viral SRC cDNA sequence from the Schmidt-Ruppin strain into exon 1 of GFAP. The GFAP promoter drives expression of the transgene in astrocytes of the brain. RT-PCR analysis of brain RNA from transgenic animals confirmed expression of the transgene. Transgene expression was also detected in lung, thymus, spleen, and gonads. (J:40335)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(GFAP-SRC)2Aag

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Three transgenic lines were established. Lines src1 and src2 carry 5 and 32 copies, respectively, of the full-length SRC sequence whereas line src3 carries 8 copies of a 3' truncated SRC sequence.

References

• Original: J:40335 Weissenberger J, et al., Development and malignant progression of astrocytomas in GFAP-v-src transgenic mice. Oncogene. 1997 May 1;14(17):2005-13
• All: 4 reference(s)