Dad1^tm1Brw
Targeted Allele Detail

Summary

• Symbol: Dad1^tm1Brw
• Name: defender against cell death 1; targeted mutation 1, Jay L Brewster
• MGI ID: MGI:2445490
• Synonyms: Dad1-Delta1
• Gene: Dad1 Location: Chr14:54472942-54491386 bp, - strand Genetic Position: Chr14, 27.7 cM
• Alliance: Dad1^tm1Brw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62083
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. (J:62083)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dad1 Mutation: 9 strains or lines available

References

• Original: J:62083 Brewster JL, et al., Deletion of Dad1 in mice induces an apoptosis-associated embryonic death. Genesis. 2000 Apr;26(4):271-8
• All: 1 reference(s)