Cer1^tm1.1Rph
Targeted Allele Detail

Summary

• Symbol: Cer1^tm1.1Rph
• Name: cerberus 1, DAN family BMP antagonist; targeted mutation 1.1, Richard P Harvey
• MGI ID: MGI:2445492
• Synonyms: Cer1^lacZ
• Gene: Cer1 Location: Chr4:82799988-82803385 bp, - strand Genetic Position: Chr4, 39.4 cM
• Alliance: Cer1^tm1.1Rph page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62081
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The floxed hygromycin gene that replaced the first coding exon was excised from Cer1^tm1Rph via in vivo cre mediated recombination. The inserted lacZ gene remained in place of sequence encoding the initiator methionine, signal sequence, prosequence, and the first cysteine of the cystine knot. The expression pattern of lacZ was similar to that of the endogenous gene. (J:62081)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cer1 Mutation: 11 strains or lines available

References

• Original: J:62081 Stanley EG, et al., Targeted insertion of a lacZ reporter gene into the mouse Cer1 locus reveals complex and dynamic expression during embryogenesis [letter]. Genesis. 2000 Apr;26(4):259-64
• All: 1 reference(s)