Cer1^tm1Belo
Targeted Allele Detail

Summary

• Symbol: Cer1^tm1Belo
• Name: cerberus 1, DAN family BMP antagonist; targeted mutation 1, Jose Antonio Belo
• MGI ID: MGI:2445497
• Synonyms: cer-l^-
• Gene: Cer1 Location: Chr4:82799988-82803385 bp, - strand Genetic Position: Chr4, 39.4 cM
• Alliance: Cer1^tm1Belo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62082
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3.5 kb restriction fragment containing the majority of exon 1 and all of exon 2 was replaced with a construct containing IRES-lacZ and neo. Mutant mice did not express lacZ due to a deletion of several nucleotides in the IRES. (J:62082)

Expression

In Mice Carrying this Mutation:

46 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cer1 Mutation: 11 strains or lines available

References

• Original: J:62082 Belo JA, et al., Cerberus-like is a secreted BMP and nodal antagonist not essential for mouse development [letter]. Genesis. 2000 Apr;26(4):265-70
• All: 8 reference(s)