Pidys^C3H/HeJ
QTL Variant Detail

Summary

• QTL variant: Pidys^C3H/HeJ
• Name: particle-induced immune disfunction; C3H/HeJ
• MGI ID: MGI:2445506
• QTL: Pidys Location: unknown Genetic Position: Chr17, cM position of peak correlated region/allele: 19.12 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C3H/HeJ

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:66469

147 SSLP markers were screened in a (C57BL/6J x C3H/HeJ)F2 intercross population to identify QTLS associated with particle-induced immune dysfunction. Animals were exposed to acid-coated carbon particles (ACP) and assessed for alveolar macrophage function. Parental strain C57BL/6J is susceptible to particle-induced immune dysfunction and exhibits decreased macrophage phagocytic function 1, 3, and 7 days after ACP exposure. Parental strain C3H/HeJ is fairly resistant. A locus showing significant linkage to this trait, Pidys, mapped to an interval on mouse Chromosome 17 between D17Mit147 (18.1 cM) and D17Mit64 (22.8 cM). Candidate genes in the region of Pidys are Hspa1b, Hspa1a, Tnf, Mcpt6, Mcpt7, and several histocompatibility genes. Pidys co-localizes with a previously identified QTL for ozone-induced bronchial hyperresponsiveness, Bhr3. A suggestive locus associated with particle-induced immune dysfunction was also identified on mouse Chromosome 11 mapping to approximately 47 cM.

References

• Original: J:66469 Ohtsuka Y, et al., Genetic linkage analysis of susceptibility to particle exposure in mice. Am J Respir Cell Mol Biol. 2000 May;22(5):574-81
• All: 1 reference(s)