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Wt3q3MH
QTL Variant Detail
Summary
QTL variant: Wt3q3MH
Name: body weight, 3 weeks, QTL 3; MH
MGI ID: MGI:2445537
QTL: Wt3q3  Location: unknown  Genetic Position: Chr17, Syntenic
Variant
origin
Strain of Specimen:  MH line
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased body weight at 3 weeks compared to C57BL/6J. (J:55483)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:55483

Authors used a composite base population from four outbred strains (NIH, ICR, CF-1 and CFW) to select for lines showing a difference in heat loss. After 15 generations of selection, the MH line showed higher heat loss, consumed more feed, were leaner and more active than the ML line of mice. C57BL/6J was chosen as the inbred line to create a resource population from a cross between a selection line and an inbred line. Average heat loss and feed intake of the C57BL/6J mice were similar to that of mice from the ML line but their body composition was similar to the MH line. To identify QTLs that are responsible for heat loss and other phenotypes related to energy balance, a complete genome wide scan was conducted in a (MH x C57BL/6J)F2 intercross (n = 560). Regions harboring QTL with the greatest effects were then evaluated in a (MH x ML)F2 intercross (n = 560). A QTL influencing body weight at 3 weeks, Wt3q3 (LOD = 6.28, 5.0% of residual variance explained) was identified with a peak at 14 cM on Chromosome 17 in the (MH x C57BL/6J)F2 intercross. The MH allele was responsible for increased body weight at 3 weeks for this QTL.

References
Original:  J:55483 Moody DE, et al., Identification of quantitative trait loci influencing traits related to energy balance in selection and inbred lines of mice. Genetics. 1999 Jun;152(2):699-711
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory