Bwq4^SM/J
QTL Variant Detail

Summary

• QTL variant: Bwq4^SM/J
• Name: body weight, QTL 4; SM/J
• MGI ID: MGI:2445552
• QTL: Bwq4 Location: unknown Genetic Position: Chr18, cM position of peak correlated region/allele: 18.83 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: SM/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased body weight compared to LG/J. (J:71465)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Candidate Genes

J:91835

The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A^vy animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A^vy genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes.

On mouse Chromosome 18, Fgf1 (19 cM) shows differential expression between the restricted and unrestricted diets on the A/A^vy background. Diabesity QTL Nidd2 (16 cM) maps near candidate gene Fgf1. Cd14 (31 cM) shows differential expression between A/a and A/A^vy animals on the unrestricted diet. Diabesity QTL Bwq4 (28 cM) maps near candidate gene Cd14.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:71465

391 (SM/J x A/J)F2 animals were genotyped at 90 polymorphic loci to identify QTLs associated with body weight. Parental strain SM/J weighs approximately 65% less than parental strain A/J. Significant linkage to body weight was detected on mouse Chromosome 8 (Bwq3) and mouse Chromosome 18 (Bwq4). Bwq3 spans 53 cM 69 cM on chromosome 8 with a peak LOD score of 4.6 at 56 cM near D8Mit88. Bwq3 appears to exhibit recessive or additive inheritance where SM/J-derived alleles are associated with increased body weight. Bwq4 spans 20 cM - 54 cM on chromosome 18 with a peak LOD score of 4.8 at 28 cM near D18Mit15. SM/J-derived alleles appear to confer increased body weight in a dominantly inherited fashion at this locus. Early growth response 1 (Egr1) and glucocorticoid receptor 1 (Nr3c1) are possible candidate genes for Bwq4. No candidate genes have been identified in the region of Bwq3. Suggestive linkages to body weight were detected on mouse Chromosomes 2, 6, 7, 15, and 19 (LOD<3.5).

References

• Original: J:71465 Anunciado RV, et al., Quantitative trait loci for body weight in the intercross between SM/J and A/J mice. Exp Anim. 2001 Jul;50(4):319-24
• All: 1 reference(s)