Nidd2^NON/LtHl
QTL Variant Detail

Summary

• QTL variant: Nidd2^NON/LtHl
• Name: non-insulin-dependent diabetes mellitus 2; NON/LtHl
• MGI ID: MGI:2445564
• QTL: Nidd2 Location: unknown Genetic Position: Chr18, cM position of peak correlated region/allele: 18.04 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: NON/LtHl

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers diabetes susceptibility and is linked to blood glucose levels at the 24-week sampling time compared to NZO/Hl. (J:48957)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Nidd2 is also consistent with an additive mode of inheritance.

Candidate Genes

J:91835

The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A^vy animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A^vy genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes.

On mouse Chromosome 18, Fgf1 (19 cM) shows differential expression between the restricted and unrestricted diets on the A/A^vy background. Diabesity QTL Nidd2 (16 cM) maps near candidate gene Fgf1. Cd14 (31 cM) shows differential expression between A/a and A/A^vy animals on the unrestricted diet. Diabesity QTL Bwq4 (28 cM) maps near candidate gene Cd14.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:48957

NON/LtHl inbred mice were selected for impaired glucose tolerance and NZO/Hl inbreds were selected for polygenic obesity, respectively. Their male F1 progeny consistently developed NIDDM (non-insulin-dependent diabetes mellitus).

A total of 193 (NZO/Hlx NON/LtHl)F2 and 201 (NON/LtHl x NZO/Hl)F2 mice were informative in identifying NIDDM susceptibility trait loci.

Nidd2 was contributed by the NON/LtHl background and mapped to an interval of mouse Chromosome 18 that contained the marker D18Mit60 with a peak LOD of approximately 5.0.

References

• Original: J:48957 Leiter EH, et al., NIDDM genes in mice: deleterious synergism by both parental genomes contributes to diabetogenic thresholds. Diabetes. 1998 Aug;47(8):1287-95
• All: 1 reference(s)