Summary |
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Variant origin |
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Variant description |
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Phenotypes |
View phenotypes and curated references for all genotypes (concatenated display).
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Expression |
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Notes |
Candidate Genes
The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/Avy animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/Avy genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. Mapping and Phenotype information for this QTL, its variants and associated markersJ:48957NON/LtHl inbred mice were selected for impaired glucose tolerance and NZO/Hl inbreds were selected for polygenic obesity, respectively. Their male F1 progeny consistently developed NIDDM (non-insulin-dependent diabetes mellitus). A total of 193 (NZO/Hlx NON/LtHl)F2 and 201 (NON/LtHl x NZO/Hl)F2 mice were informative in identifying NIDDM susceptibility trait loci.Nidd2 was contributed by the NON/LtHl background and mapped to an interval of mouse Chromosome 18 that contained the marker D18Mit60 with a peak LOD of approximately 5.0. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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