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Nidd3NON/LtHl
QTL Variant Detail
Summary
QTL variant: Nidd3NON/LtHl
Name: non-insulin-dependent diabetes mellitus 3; NON/LtHl
MGI ID: MGI:2445566
QTL: Nidd3  Location: unknown  Genetic Position: Chr11, Syntenic
Variant
origin
Strain of Specimen:  NON/LtHl
Variant
description
Allele Type:    QTL
Mutation:    Undefined
 
Mutation detailsThis allele confers diabetes resistance and is linked to serum immunoreactive insulin (IRI) and body weight loss at the 24-week sampling time compared to NZO/Hl.
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:48957

NON/LtHl inbred mice were selected for impaired glucose tolerance and NZO/Hl inbreds were selected for polygenic obesity, respectively. Their male F1 progeny consistently developed NIDDM (non-insulin-dependent diabetes mellitus).

A total of 193 (NZO/Hlx NON/LtHl)F2 and 201 (NON/LtHl x NZO/Hl)F2 mice were informative in identifying NIDDM susceptibility trait loci.

Nidd3 was contributed by the NON/LtHl background and mapped to an interval of mouse Chromosome 11 that contained a peak at marker D11Mit261 (LOD 8.9) and a peak at marker D11Mit41 (LOD 11.1).

References
Original:  J:48957 Leiter EH, et al., NIDDM genes in mice: deleterious synergism by both parental genomes contributes to diabetogenic thresholds. Diabetes. 1998 Aug;47(8):1287-95
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory