Nidd3^NZO/Hl
QTL Variant Detail

Summary

• QTL variant: Nidd3^NZO/Hl
• Name: non-insulin-dependent diabetes mellitus 3; NZO/Hl
• MGI ID: MGI:2445567
• QTL: Nidd3 Location: unknown Genetic Position: Chr11, Syntenic

Variant origin

• Strain of Specimen: NZO/Hl

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers diabetes susceptibility and is linked to serum immunoreactive insulin (IRI) and body weight gain at the 24-week sampling time compared to NON/LtHl. (J:48957)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:48957

NON/LtHl inbred mice were selected for impaired glucose tolerance and NZO/Hl inbreds were selected for polygenic obesity, respectively. Their male F1 progeny consistently developed NIDDM (non-insulin-dependent diabetes mellitus).

A total of 193 (NZO/Hlx NON/LtHl)F2 and 201 (NON/LtHl x NZO/Hl)F2 mice were informative in identifying NIDDM susceptibility trait loci.

Nidd3 was contributed by the NON/LtHl background and mapped to an interval of mouse Chromosome 11 that contained a peak at marker D11Mit261 (LOD 8.9) and a peak at marker D11Mit41 (LOD 11.1).

References

• Original: J:48957 Leiter EH, et al., NIDDM genes in mice: deleterious synergism by both parental genomes contributes to diabetogenic thresholds. Diabetes. 1998 Aug;47(8):1287-95
• All: 2 reference(s)