Pla2g1b^tm1Dyh
Targeted Allele Detail

Summary

• Symbol: Pla2g1b^tm1Dyh
• Name: phospholipase A2, group IB, pancreas; targeted mutation 1, David Y Hui
• MGI ID: MGI:2445572
• Synonyms: PLA2(-)
• Gene: Pla2g1b Location: Chr5:115604321-115612781 bp, + strand Genetic Position: Chr5, 56.1 cM, cytoband F1-G1.1
• Alliance: Pla2g1b^tm1Dyh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68430
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 2 was disrupted by the insertion of a neomycin selection cassette. Neither protein nor phospholipid hydrolytic activity was detected in homozygous mutant mice by Western blot analysis or biochemical assay of pancreatic extracts. (J:68430)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pla2g1b Mutation: 15 strains or lines available

References

• Original: J:68430 Richmond BL, et al., Compensatory phospholipid digestion is required for cholesterol absorption in pancreatic phospholipase A(2)-deficient mice. Gastroenterology. 2001 Apr;120(5):1193-202
• All: 6 reference(s)