Atf4^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Atf4^tm1Aki
• Name: activating transcription factor 4; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:2445679
• Synonyms: ATF4(-)
• Gene: Atf4 Location: Chr15:80139385-80141742 bp, + strand Genetic Position: Chr15, 37.85 cM
• Alliance: Atf4^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:56007
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 0.8 kb of sequence encoding the basic leucine zipper was deleted by homologous recombination of a construct containing a neomycin selection cassette. Transcript was undetected by Northern blot analysis of homozygous mutant mice. (J:56007)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atf4 Mutation: 22 strains or lines available

References

• Original: J:56007 Tanaka T, et al., Targeted disruption of ATF4 discloses its essential role in the formation of eye lens fibres. Genes Cells. 1998 Dec;3(12):801-10
• All: 9 reference(s)