Tg(Camk2a-cre/ERT2)1Casa
Transgene Detail

Summary

• Symbol: Tg(Camk2a-cre/ERT2)1Casa
• Name: transgene insertion 1, Emilio Casanova
• MGI ID: MGI:2445680
• Synonyms: ERiCreER, Tg(Camk2a-cre/Esr1)1Casa
• Transgene: Tg(Camk2a-cre/ERT2)1Casa Location: unknown
• Alliance: Tg(Camk2a-cre/ERT2)1Casa page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Camk2a-cre/ERT2)1Casa expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Camk2a

• Mutation details: The transgene consists of a BAC vector carrying a tamoxifen-inducible cre recombinase gene under the control of Camk2a regulatory elements, an eGFP cassette, and a bovine growth hormone polyadenylation signal. The cre recombinase gene is flanked by 2 ERT2 ligand binding domains. The Camk2a promoter targets transgene expression to the brain. High expression was observed in the hippocampus and cortex, intermediate expression was observed in the striatum, thalamus, and hypothalamus, and no detectable expression was observed in the cerebellum. This transgenic line carries 8 copies of the integrated construct. (J:80195)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Camk2a (species not specified) Summary of all recombinase alleles driven by Camk2a. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:80195 Casanova E, et al., ER-based double icre fusion protein allows partial recombination in forebrain. Genesis. 2002 Nov;34(3):208-14
• All: 2 reference(s)