Tg(Scgb1a1-rtTA)1Jaw
Transgene Detail

Summary

• Symbol: Tg(Scgb1a1-rtTA)1Jaw
• Name: transgene insertion 1, Jeffrey A Whitsett
• MGI ID: MGI:2445707
• Synonyms: CC10-rtTA, CCSP-rtTA, CCSP^tg, Scgb1a1-rtTA, Tg(Ugb-rtTA)1Jaw
• Transgene: Tg(Scgb1a1-rtTA)1Jaw Location: unknown
• Alliance: Tg(Scgb1a1-rtTA)1Jaw page

Absence of proliferation during goblet cell hyperplasia in Tg(Scgb1a1-rtTA)1Jaw/0 Tg(tetO-Spdef)1Jaw/0 mice

Show the 1 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: 129 and C57BL/6

Transgene description

• Transgene Type: Transgenic (Transactivator)
• Mutation: Insertion
• Mutation details: The transgene is composed of 2.3 kb of rat Ugb (Scgb1a1) promoter, a reverse tetracycline responsive transactivator gene (rt-TA), and 2 kb of human growth hormone sequences, which includes introns and a polyadenylation signal. Transgene expression was confirmed by RT-PCR analysis. The rat Scgb1a1 promoter is active in respiratory epithelial cells. (J:61736)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Tg(Scgb1a1-rtTA)1Jaw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available

Notes

Phenotypic Similarity to Human Syndrome: Bronchopulmonary dysplasia (J:130523, J:171488).

References

• Original: J:61736 Tichelaar JW, et al., Conditional expression of fibroblast growth factor-7 in the developing and mature lung. J Biol Chem. 2000 Apr 21;275(16):11858-64
• All: 218 reference(s)