Tg(SFTPC-rtTA)5Jaw
Transgene Detail

Summary

• Symbol: Tg(SFTPC-rtTA)5Jaw
• Name: transgene insertion 5, Jeffrey A Whitsett
• MGI ID: MGI:2445716
• Synonyms: hSPC-rtTA⁺, SFTPC-rtTA, Sp-c-rtta, SP-CrtTA, SPC-rtTA, SP-C-rtTA mice (Line 1), SP-C-rtTA^tg, SP-CrtTA^tg, Tg(SFTPC-rtTA)1Jaw
• Transgene: Tg(SFTPC-rtTA)5Jaw Location: unknown
• Alliance: Tg(SFTPC-rtTA)5Jaw page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Transactivator)
• Mutation: Insertion
• Mutation details: The transgene is composed of 3.7 kb of human SFTPC promoter, a reverse tetracycline responsive transactivator gene (rt-TA), and a 0.45 kb SV40 polyadenylation signal. Transgene expression was confirmed by RT-PCR analysis. The human SFTPC promoter is active in respiratory epithelial cells. (J:61736)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Tg(SFTPC-rtTA)5Jaw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available

References

• Original: J:61736 Tichelaar JW, et al., Conditional expression of fibroblast growth factor-7 in the developing and mature lung. J Biol Chem. 2000 Apr 21;275(16):11858-64
• All: 172 reference(s)