Rbp4^tm1Gott
Targeted Allele Detail

Summary

• Symbol: Rbp4^tm1Gott
• Name: retinol binding protein 4, plasma; targeted mutation 1, Max E Gottesman
• MGI ID: MGI:2445721
• Synonyms: RBP^-
• Gene: Rbp4 Location: Chr19:38105077-38113729 bp, - strand Genetic Position: Chr19, 32.75 cM, cytoband D1
• Alliance: Rbp4^tm1Gott page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57513
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The endogenous locus was disrupted by the insertion of a neomycin cassette that replaced sequence extending from 252 bp upstream of the TATA box through exon 2. While neither normal transcript or protein was detected by Northern or Western blot analyses of homozygous mutant mice, an elongated transcript and a 28 kDa protein were observed. Analysis of labeled retinol in serum fractions and in vivo binding experiments indicated that the mutant protein was present in high molecular weight aggregates and did not function to transport retinol in circulation. (J:57513)

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rbp4 Mutation: 21 strains or lines available

References

• Original: J:57513 Quadro L, et al., Impaired retinal function and vitamin A availability in mice lacking retinol-binding protein. EMBO J. 1999 Sep 1;18(17):4633-44
• All: 26 reference(s)