Rarg^tm4Ipc
Targeted Allele Detail

Summary

• Symbol: Rarg^tm4Ipc
• Name: retinoic acid receptor, gamma; targeted mutation 4, Pierre Chambon
• MGI ID: MGI:2445724
• Synonyms: RARgamma1^-
• Gene: Rarg Location: Chr15:102143373-102165891 bp, - strand Genetic Position: Chr15, 57.4 cM, cytoband E-F3
• Alliance: Rarg^tm4Ipc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:42773
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: An isoform specific disruption was achieved by the insertion of a promoterless neomycin selection cassette into exon 3 via homologous recombination. Whereas gamma1 transcript was undetected by RT-PCR analysis of homozygous mutant mice, gamma2 mRNA was readily amplified. An RNAse protection assay further indicated the absence of the gamma1 isoform. (J:42773)

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rarg Mutation: 151 strains or lines available

References

• Original: J:42773 Subbarayan V, et al., Limited specificity and large overlap of the functions of the mouse RAR gamma 1 and RAR gamma 2 isoforms. Mech Dev. 1997 Aug;66(1-2):131-42
• All: 1 reference(s)